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Rosenmund Reduction

Gain insights into difficult chemistry
Gain insights into successful scale-up when reaction conditions and unstable intermediates prohibit or complicate extractive sampling and offline measurements.
Supersaturation monitoring with ReactIR ATR-FTIR

Bio-Based Materials in a Synthetic World: Activity and Longevity in Functional Films

Using ReactIR in Chemical Development - GlaxoSmithKline

Bob Cooley, GlaxoSmithKline



Controlling Particle Size and Polymorph Form in Active Pharmaceutical Ingredients (API) Production

Adam J. Fine, Kevin D. Seibert, and Jean W. Tom, Merck & Co., Inc.



Real-time in situ FTIR analysis of liquid phase catalytic reactions

Reductive amination scale-up

Enhance understanding of difficult chemistry with in situ IR products
Gain insights into successful scale-up when reaction conditions and unstable intermediates prohibit or complicate extractive sampling and offline measurements.
Reducing your Risks: Optimization of Highly Reactive Chemistry

Online Monitoring of Crystallization of a Polymorphic Compound Using FBRM®, PVM®, and Raman

A.T. Andrews, P. Fernandez, M. Midler, R. Osifchin, S. Patel, Y.-K. Sun, H.H. Tung, J. Wang, and G.X. Zhou, Merck & Co., Inc.
ReactIR™ in situ reaction analysis applications brochure

Nitrobenzene Hydrogenation, Chiral Hydrogenation of a Carboxylic Acid, Grignard Reagent, Formation of Chiral Ester via Alcoholysis of a Ketene
Selective Chlorination

Chlorinations are common processes for producing intermediates and active ingredients in the agricultural, pharmaceutical, and fine chemical industries. The ability to detemine the chlorine substitution position and the relative degree is critical to formation of the desired product as well as to control the formation of side products. Selectivity and yield of the reaction can be optimized by timely endpoint determination.

Amide Synthesis via a Reactive Acid Chloride Intermediate

Определение параметров противорастворительной кристаллизации в процессе обработки

Nitrobenzyl reduction

Gain insights into difficult chemistry
Gain insights into reaction performance and variables
when conditions prohibit or complicate extractive sampling and offline measurements.