There is increasing pressure to develop manufacturing scale crystallization processes with lower cost and higher quality. One of the most troublesome yet critical unit operations in the manufacturing chain is the crystallization step. Through implementation of in-process particle characterization technology, crystallization processes can be monitored and optimized in real time ensuring less batch failures, greater production throughput and higher product quality.
Production Crystallization case studies were presented for the following applications:
- Ensure batch-to-batch consistency
- Target a desired crystal endpoint distribution
- Monitoring and optimizing seed loading and dispersion
- Optimizing filtration rates and product throughput
- Correlating crystal distribution data to bulk powder properties
On-Demand Webinar Presenter
Your online presenter, Brian O’Sullivan, has extensive experience in the implementation of in situ technologies in batch crystallization design and development. His Ph.D. focus was the application and utilization of in situ analytics for understanding, developing and optimizing batch crystallization processes with particular emphasis on polymorphic crystallization processes.