Flow Chemistry Congress

METTLER TOLEDO is pleased to be presenting and exhibiting at the Flow Chemistry Congress and Exhibition - under the auspices of the Flow Chemistry Society. The Flow Chemistry Congress focuses on the use of enabling technologies in synthetic chemistry and continuous flow chemistry.

Enhanced Development and Control of Continuous Processes using Real Time In Situ FTIR Analytics – Dr. Dominique Hebrault

The combination of flow reactor technology and in situ analysis equipped with multivariate analysis and data-to-information software modules, are used in flow chemistry and crystallization design to minimize waste, improve reaction output, and decrease the formation of by-products

ATR-FTIR was used as a convenient, specific, inline monitoring technique to examine various aspects, challenges, and opportunities posed by flow chemistry: Dispersion in the column, rapid screening of reaction conditions, reactive intermediate identification, hazardous compound detection to protect the experimenter, microliter scales experiments. To this end, several chemical reactions were investigated. This initial study showed that the time it usually takes to optimize reaction conditions was shortened as a result. Thanks to the fast response time and the structural information contained in each of the many reaction mixture spectra obtained, short-lived intermediates were observed in situ, which helped gain a better understanding of reaction mechanism. In a later investigation, formation of a pyrazole derivative, the use of ATR-FTIR has enabled precise control of reagent streams addition in a complex multi-step reactions sequence. For the first time, it is therefore possible to control pumps to dispense reagents based upon the real time concentration of reaction intermediates in multi-step processes. As a result of this high level of control via inline monitoring, multi-step sequences are run more efficiently. For instance, in the event of a reaction failure, precious material would be saved since the lowered concentration of intermediate would be accounted for in real-time.

Please visit Booth 7 to see continuous flow chemistry technologies on display:

• FlowIR™ - analyze continuous flow chemistry in real-time
• DS Micro Flow Cell for ReactIR™ 15 – continuous flow chemistry information
  

Webinar spotlight – The Application of the ReactIR™ Flow Cell to Continuous Processing Technology
Prof. Steven V. Ley presents ReactIR™ DS Micro Flow Cell as a convenient inline analytical tool for continuous flow chemistry processing.